Around 40-50% of newly-diagnosed cancer patients suffer some sort of depression or anxiety. Antidepressants have little effect, particularly on the “existential” depression that can lead some to feel their lives are meaningless, and to contemplate suicide.
Psilocybin produced significant decreases in clinician-rated and self-rated measures of depression, anxiety and mood disturbance, and increases in quality of life, death acceptance and optimism; effects sustained for at least six months.
Addiction to alcohol, tobacco, and other drugs is the leading preventable cause of death and disability globally; the economic costs of substance use disorders are over half a trillion dollars per year in the US alone, including factors like health care costs, lost productivity, crime, and law enforcement.
The psychedelic method, rather than emphasizing resolution of childhood conflicts or traumatic experiences, used higher doses of hallucinogens. Administered on one or a few occasions with the goal of inducing a “mystical” experience, they often induced lasting change in habitual patterns of thought, emotional response, and behavior.
PTSD is a debilitating anxiety disorder characterized by re-experiencing, hyperarousal and avoidance symptoms. In the US, the lifetime prevalence of PTSD in the general population is between 6% and 10%. Existing therapies for PTSD are ineffective for 25-50% of patients in clinical trials.
Preliminary studies have shown that MDMA, in conjunction with psychotherapy, can help people overcome PTSD, and possibly other disorders as well. MDMA is known for increasing feelings of trust and compassion towards others, which could make an ideal adjunct to psychotherapy for PTSD.
In the last few years, the world has been waking up to the power of psychedelic micro-dosing, with a particular focus on LSD. Extensive anecdotal reports suggest that micro-dosing can improve mood, enhance cognition, increase productivity, and boost creativity.
So far, no scientific research has been done to confirm these effects.
Scientists are about to find out how Silicon Valley's LSD habit really affects productivity
My fear of dying was gone': Former Cancer patient says psychedelic drugs helped him cope with end of life anxiety.
Testimonial: The experience did not restore him to his former life, he said, “but I have a greater sense of peace of what might come. I’m very grateful, beyond words, for this trial. But you have to approach the session with the right intentions of why you’re doing it. Because you’re going to meet yourself. ”